Michael York

Sherlock Holmes (voice)

Malcolm McDowell

Professor Moriarity (voice)

John Rhys-Davies

Dr. Watson (voice)

Billy West

Tom (voice)

Grey DeLisle-Griffin

Red (voice)

Phil LaMarr

Spike / Policeman (voice)

Kath Soucie

Tuffy (voice)

Jeff Bergman

Butch / Droopy (voice)

Greg Ellis

Tin / Sergeant (voice)

Jess Harnell

Pan / Brett Jeremy (voice)